The DodoNA Project
“DodoNA” is a metaphor. The oldest oracle of ancient Greece was at Dodona. Priestesses would interpret the rustling of leaves of an oak tree to predict the future and to advise the correct actions to be taken. Just as at DodoNA, we can interpret subtle variations in DNA, the “tree of life”, to predict outcomes and to advise our patients the correct actions to be taken. Through DNA predictions, we will improve neurological health. Specifically, we are developing medical informatics tools to capture standardized data via routine office visits that measure the progression and outcomes of patients with 11 well-defined neurological disorders (one per Neurology program; Parkinson’s, migraine, MS, restless legs syndrome, mild traumatic brain injury, stroke, epilepsy, Alzheimer’s, ALS, brain tumors, to be named). DodoNA is a clinical practice initiative (note writing and workflow efficiencies) and a quality initiative (Best Practices). It is also a research initiative. Namely, we will invite up to 1,000 subjects for each of the 11 disorders (11,000 subjects total) to provide via informed consent a blood sample for DNA extraction and storage, and permission to associate information in their blood with information in their medical records (for the purposes of developing molecular prognostics and therapeutics).Principal Investigator: Demetrius M. Maraganore, MD
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